GuavaH

Genomic Utility for Association and Viral Analyses in HIV

There is an ever-increasing volume of data on host genes that are modulated during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV infection. This public resource supports queries on genome-wide genetic variation and gene expression profile across multiple phenotypes relevant to HIV biology.

Query gene, marker or region
Enter gene name, rs number or a region in the format of chr:start-stop (max 5Mb range).
Filter for study. For details of each study refer to the table below. Some of the datasets are not yet published, if you want to access them, we kindly ask you to contact us (contact at guavah.org) .

Phenotypes and studies in the database

HIV set point viral load

HIV-1 viral load at set point is a strong correlate of disease progression.
Study name Sample Count Reference Technology Public
ICGH2 6315 http://www.pnas.org/content/112/47/14658 Illumina, 1kg imputed Yes

EVS healthy controls

Study name Sample Count Reference Technology Public
EVS 6503 control data from evs.gs.washington.edu see evs.gs.washington.edu Yes

HIV sequence variation. Best p-value per SNP shown.

Associations between human and HIV genomes.
Study name Sample Count Reference Technology Public
G2G 1071 Bartha et al. eLife 2013 Illumina / Affymetrix GWAS chips. 1KG imputed Yes

viral load setpoint

Study name Sample Count Reference Technology Public
EXPR_VL_PlosPath 127 see PLoS Pathog 6(2): e1000781 Illumina HumanWG-6 v3.0 expression beadchip Yes

Gene-level genetic variation in HIV positive population

Study name Sample Count Reference Technology Public
SHCS (Exome variations) 391 Unpublished Illumina HiSeq2000 w/ Truseq 65Mb Yes